Wm. Craig Byrdwell, phd

The following results were obtained from a search of (“Vitamin D” AND “Liquid Chromatography” AND “Mass Spectrometry”).  Although not comprehensive, this list gives a good start for a search of the literature in field of Vitamin D analysis by Liquid Chromatography/ Mass Spectrometry.

1. Hollis, B.W., Horst, R.L. The assessment of circulating 25(OH)D and 1,25(OH)2D: Where we are and where we are going, (2007) Journal of Steroid Biochemistry and Molecular Biology, 103 (3-5), Pages  473-476.

2. Singh, R.J., Taylor, R.L., Reddy, G.S., Grebe, S.K.G. C-3 epimers can account for a significant proportion of total circulating 25-hydroxyvitamin D in infants, complicating accurate measurement and interpretation of vitamin D status, (2006) Journal of Clinical Endocrinology and Metabolism, 91 (8), pp. 3055-3061.

3. Tsugawa, N., Okano, T. Bone and bone related biochemical examinations. Hormone and hormone related substances. Vitamin D (25D, 1,25D); measurements and clinical significances, (2006) Clinical calcium, 16 (6), pp. 36-42.

4. Lensmeyer, G.L., Wiebe, D.A., Binkley, N., Drezner, M.K. HPLC method for 25-hydroxyvitamin D measurement: Comparison with contemporary assays, (2006) Clinical Chemistry, 52 (6), pp. 1120-1126.

5. Saenger, A.K., Laha, T.J., Bremner, D.E., Sadrzadeh, S.M.H. Quantification of serum 25-hydroxyvitamin D2 and D3 using HPLC-tandem mass spectrometry and examination of reference intervals for diagnosis of vitamin D deficiency, (2006) American Journal of Clinical Pathology, 125 (6), pp. 914-920.

6. Perales, S., Alegría, A., Barbera, R., Farré, R. Review: Determination of vitamin D in dairy products by high performance liquid chromatography, (2005) Food Science and Technology International, 11 (6), Pages 451-462.

7. Murao, N., Ishigai, M., Sekiguchi, N., Takahashi, T., Aso, Y. Ferrocene-based Diels-Alder derivatization for the determination of 1a-hydroxyvitamin D3 in rat plasma by high-performance liquid chromatography-electrospray tandem mass spectrometry, (2005) Analytical Biochemistry, 346 (1), Pages 158-166.

8. Maunsell, Z., Wright, D.J., Rainbow, S.J. Routine isotope-dilution liquid chromatography-tandem mass spectrometry assay for simultaneous measurement of the 25-hydroxy metabolites of vitamins D2 and D3, (2005) Clinical Chemistry, 51 (9), Pages 1683-1690. 

9. Terry, A.H., Sandrock, T., Meikle, A.W. Measurement of 25-hydroxyvitamin D by the Nichols ADVANTAGE, DiaSorin LIAISON, DiaSorin RIA, and liquid chromatography-tandem mass spectrometry, (2005) Clinical Chemistry, 51 (8), pp. 1565-1566.

10. Tsugawa, N., Suhara, Y., Kamao, M., Okano, T. Determination of 25-hydroxyvitamin D in human plasma using high-performance liquid chromatography-tandem mass spectrometry, (2005) Analytical Chemistry, 77 (9), Pages 3001-3007.  

11. Carter, G.D., Carter, R., Jones, J., Berry, J. How accurate are assays for 25-hydroxyvitamin D? Data from the international vitamin D external quality assessment scheme, (2004) Clinical Chemistry, 50, Pages 2195-2197

12. Masuda, S., Kaufmann, M., Byford, V., Gao, M., St-Arnaud, R., Arabian, A., Makin, H.L.J., (...), Jones, G. Insights into Vitamin D metabolism using cyp24 over-expression and knockout systems in conjunction with liquid chromatography/mass spectrometry (LC/MS), (2004) Journal of Steroid Biochemistry and Molecular Biology, 89-90, Pages 149-153.  

13. Heudi, O., Trisconi, M.-J., Blake, C.-J. Simultaneous quantification of Vitamins A, D3 and E in fortified infant formulae by liquid chromatography-mass spectrometry, (2004) Journal of Chromatography A, 1022 (1-2), Pages 115-123. 

14. King, J.M., Min, D.B. Riboflavin-photosensitized singlet oxygen oxidation product of vitamin D2, (2002) JAOCS, Journal of the American Oil Chemists' Society, 79 (10), Pages 983-987.

15. Shimada, K., Higashi, T. High-performance liquid chromatography/mass spectrometry of vitamin D compounds employing derivatization with Cookson-type reagents, (2002) Bunseki Kagaku, 51 (7), Pages 487-493. 

16. Shimada, K., Mitamura, K., Higashi, T. Gas chromatography and high-performance liquid chromatography of natural steroids, (2001) Journal of Chromatography A, 935 (1-2), Pages 141-172. 

17. Kissmeyer, A.-M., Sonne, K. Sensitive analysis of 1a,25-dihydroxyvitamin D3 in biological fluids by liquid chromatography-tandem mass spectrometry, (2001) Journal of Chromatography A, 935 (1-2), Pages 93-103. 

18. Wang, T., Bengtsson, G., Kärnefelt, I., Björn, L.O. Provitamins and vitamins D2 and D3 in Cladina spp. over a latitudinal gradient: Possible correlation with UV levels, (2001) Journal of Photochemistry and Photobiology B: Biology, 62 (1-2), Pages 118-122.  

19. Kamao, M., Tatematsu, S., Reddy, G.S., Hatakeyama, S., Sugiura, M., Ohashi, N., Kubodera, N., Okano, T. Isolation, identification and biological activity of 24R,25-dihydroxy-3-epi-vitamin D3: A novel metabolite of 24R,25-dihydroxyvitamin D3 produced in rat osteosarcoma cells (UMR 106), (2001) Journal of Nutritional Science and Vitaminology, 47 (2), Pages 108-115. 

20. Higashi, T., Miura, K., Kikuchi, R., Shimada, K., Hiyamizu, H., Ooi, H., Iwabuchi, Y., (...), Kubodera, N. Characterization of new conjugated metabolites in bile of rats administered 24,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3, (2000) Steroids, 65 (5), Pages 281-294.

21. Kissmeyer, A.-M., Sonne, K., Binderup, E. Determination of the vitamin D analog EB 1089 (seocalcitol) in human and pig serum using liquid chromatography-tandem mass spectrometry, (2000) Journal of Chromatography B: Biomedical Sciences and Applications, 740 (1), Pages 117-128. 

22. Song, D., Kohlhof, K. Application of two-dimensional high-performance liquid chromatography-mass spectrometry with particle beam interface, (1999) Journal of Chromatography B: Biomedical Sciences and Applications, 730 2, Pages 141-151. 

23. Higashi, T., Miura, K., Kitahori, J., Shimada, K. Usefulness of derivatization in high-performance liquid chromatography/tandem mass spectrometry of conjugated vitamin D metabolites, (1999) Analytical Sciences, 15 (7), Pages 619-623. 

24. Sekimoto, H., Siu-Caldera, M.-L., Weiskopf, A., Vouros, P., Muralidharan, K.R., Okamura, W.H., Uskokovic, M.R., Reddy, G.S. 1a,25-Dihydroxy-3-epi-vitamin D3: In vivo metabolite of 1a,25-dihydroxyvitamin D3 in rats, (1999) FEBS Letters, 448 (2-3), Pages 278-282. 

25. Lehmann, B., Pietzsch, J., Kämpf, A., Meurer, M. Human keratinocyte line HaCaT metabolizes 1?-hydroxyvitamin D3 and vitamin D3 to 1?,25-dihydroxyvitamin D3 (calcitriol), (1998) Journal of Dermatological Science, 18 (2), Pages 118-127.  

26. Mawer, E.B., Jones, G., Davies, M., Still, P.E., Byford, V., Schroeder, N.J., Makin, H.L.J., (...), Knutson, J.C. Unique 24-hydroxylated metabolites represent a significant pathway of metabolism of vitamin D2 in humans: 24-Hydroxyvitamin D2 and 1,24- dihydroxyvitamin D2 detectable in human serum, (1998) Journal of Clinical Endocrinology and Metabolism, 83 (6), Pages 2156-2166.  

27. St-Arnaud, R., Messerlian, S., Moir, J.M., Omdahl, J.L., Glorieux, F.H. The 25-hydroxyvitamin D 1-alpha-hydroxylase gene maps to the pseudovitamin D-deficiency rickets (PDDR) disease locus, (1997) Journal of Bone and Mineral Research, 12 (10), Pages 1552-1559. *Highly Cited

28. Wang, K., Davis, P.P., Crews, T., Gabriel, L., Edom, R.W. An electron-capture dienophile derivatization agent for increasing sensitivity: Determination of a vitamin D analog (Ro 24-2090) in plasma samples with liquid chromatography/mass spectrometry, (1996) Analytical Biochemistry, 243 (1), Pages 28-40. 

29. Masuda, S., Byford, V., Kremer, R., Makin, H.L.J., Kubodera, N., Nishii, Y., Okazaki, A., (...), Jones, G. In vitro metabolism of the vitamin D analog, 22-oxacalcitriol, using cultured osteosarcoma, hepatoma, and keratinocyte cell lines, (1996) Journal of Biological Chemistry, 271 (15), Pages 8700-8708.

30. Yeung, B., Vouros, P., Siu-Caldera, M.-L., Reddy, G.S. Characterization of the metabolic pathway of 1,25-dihydroxy-16-ene vitamin D3 in rat kidney by on-line high performance liquid chromatography-electrospray tandem mass spectrometry, (1995) Biochemical Pharmacology, 49 (8), Pages 1099-1110.

31. Kobayashi, N., Mano, H., Imazu, T., Shimada, K. Tandem immunoaffinity chromatography for plasma 1a,25-dihydroxyvitamin D3 utilizing two antibodies having different specificities: A novel and powerful pretreatment tool for 1a,25-dihydroxyvitamin D3 radioreceptor assays, (1995) Journal of Steroid Biochemistry and Molecular Biology, 54 (5-6), Pages 217-226. 

32. Yeung, B., Vouros, P., Reddy, G. Derivatization of vitamin D metabolites for analysis by capillary HPLC-tandem mass spectrometry, (1994) American Laboratory, 26 (11).

33. Schroeder, N.J., Trafford, D.J.H., Cunningham, J., Jones, G., Makin, H.L.J. In vivo dihydrotachysterol2 metabolism in normal man: 1a- and 1b- hydroxylation of 25-hydroxydihydrotachysterol2 and effects on plasma parathyroid hormone and 1a,25-dihydroxyvitamin D3 concentrations, (1994) Journal of Clinical Endocrinology and Metabolism, 78 (6), Pages 1481-1487. 

34. Vreeken, R.J., Honing, M., Van Baar, B.L.M., Ghijsen, R.T., De Jong, G.J., Brinkman Th., U.A. On-line post-column Diels-Alder derivatization for the determination of vitamin D3 and its metabolites by liquid chromatography/thermospray mass spectrometry, (1993) Biological Mass Spectrometry, 22 (11), Pages 621-632.

35. Yeung, B., Vouros, P., Reddy, G.S. Characterization of vitamin D3 metabolites using continuous-flow fast atom bombardment tandem mass spectrometry and high-performance liquid chromatography, (1993) Journal of Chromatography, 645 (1), Pages 115-123.  

36. Vicchio, D., Yergey, A., O'Brien, K., Allen, L., Ray, R., Holick, M. Quantification and kinetics of 25-hydroxyvitamin D3 by isotope dilution liquid chromatography/thermospray mass spectrometry, (1993) Biological Mass Spectrometry, 22 (1), Pages 53-58.  

37. Qaw, F., Calverley, M.J., Schroeder, N.J., Trafford, D.J.H., Makin, H.L.J., Jones, G. In vivo metabolism of the vitamin D analog, dihydrotachysterol. Evidence for formation of 1a,25- and 1b,25-dihydroxy-dihydrotachysterol metabolites and studies of their biological activity, (1993) Journal of Biological Chemistry, 268 (1), Pages 282-292.  

38. Trafford, D.J.H., Coldwell, R.D., Makin, H.L.J. Gas chromatography-mass spectrometry in the investigation of on-column dehydration of steroid hormones during gas-liquid chromatography, (1991) Journal of Pharmaceutical and Biomedical Analysis, 9 (10-12), Pages 1095-1105. 

39. Watson, D., Setchell, K.D.R., Ross, R. Analysis of vitamin D and its metabolites using thermospray liquid chromatography/mass spectrometry, (1991) Biomedical Chromatography, 5 (4), Pages 153-160. 

40. Shimada, K., Kobayashi, N. Recent advances in the analysis of vitamin D metabolites, (1991) Trends in Analytical Chemistry, 10 (3), Pages 103-105.  

41. Reddy, G.S., Tserng, K.-Y. 24,25,28-Trihydroxyvitamin D2 and 24,25,26-trihydroxyvitamin D2: Novel metabolites of vitamin D2, (1990) Biochemistry, 29 (4), Pages 943-949.  

42. Miller, B.E., Chin, D.P., Jones, G. 1,25-Dihydroxyvitamin D3 metabolism in a human osteosarcoma cell line and human bone cells, (1990) Journal of Bone and Mineral Research, 5 (6), Pages 597-608. 

43. Porteous, C., Trafford, D.J.H., Makin, H.L.J., Cunningham, J., Jones, G. Use of mass spectrometry in the identification of in vivo and in vitro metabolites of dihydrotachysterol3 in the rat, (1988) Biomedical and Environmental Mass Spectrometry, 16 (1-12) SPEC. ISS., Pages 87-92. 

44. De Leenheer, A.P., Nelis, H.J., Lambert, W.E., Bauwens, R.M. Chromatography of fat-soluble vitamins in clinical chemistry, (1988) Journal of Chromatography - Biomedical Applications, 429, Pages 3-58. 

45. Coldwell, R.D., Trafford, D.J.H., Varley, M.J., Makin, H.L.J., Kirk, D.N. The measurement of vitamin D2 and D3 and seven major metabolites in a single sample of human plasma using gas chromatography/mass spectrometry, (1988) Biomedical and Environmental Mass Spectrometry, 16 (1-12) SPEC. ISS., Pages 81-85. 

46. Lohnes, D., Jones, G. Side chain metabolism of vitamin D3 in osteosarcoma cell line UMR-106. Characterization of products, (1987) Journal of Biological Chemistry, 262 (30), Pages 14394-14401. 

47. Reddy, G.S., Tserng, K.-Y. Isolation and identification of 1,24,25-trihydroxyvitamin D2, 1,24,25,28-tetrahydroxyvitamin D2, and 1,24,25,26-tetrahydroxyvitamin D2: New metabolites of 1,25-dihydroxyvitamin D2 produced in rat kidney, (1986) Biochemistry, 25 (18), Pages 5328-5336.

48. Horst, R.L., Reinhardt, T.A., Ramberg, C.F. 24-Hydroxylation of 1,25-dihydroxyergocalciferol. An unambiguous deactivation process, (1986) Journal of Biological Chemistry, 261 (20), Pages 9250-9256. Cited 6 times.

49. Le Boulch, N., Cancela, L., Miravet, L., Lange, C. Assessment of vitamin D sulphate in human milk using desorption chemical ionization mass spectrometry, (1986) Biomedical Mass Spectrometry, 13 (2), Pages 53-56. 

50. Shiina, Y., Miyaura, C., Tanaka, H. Mechanism of the differentiating action of 25-hydroxyvitamin D3 endoperoxides in human myeloid leukemia cells (HL-60), (1985) Journal of Medicinal Chemistry, 28 (9), Pages 1153-1158.

51. Kobayashi, T. Studies on the micro-analysis of vitamin D and related compounds in foods and biological materials and its application to nutritional sciences, (1985) Vitamins, 59 (9), Pages 435-449.

52. Axelson, M. 25-Hydroxyvitamin D3 3-sulphate is a major circulating form of vitamin D in man, (1985) FEBS Letters, 191 (2), Pages 171-175. 

53. Delvin, E.E., Arabian, A., Glorieux, F.H., Mamer, O.A. In vitro metabolism of 25-hydroxycholecalciferol by isolated cells from human decidua, (1985) Journal of Clinical Endocrinology and Metabolism, 60 (5), Pages 880-885.

54. Coldwell, R.D., Trafford, D.J.H., Makin, H.L.J. Specific mass fragmentographic assay for 25,26-dihydroxyvitamin D in human plasma using a deuterated internal standard, (1985) Journal of Chromatography - Biomedical Applications, 338 (2), Pages 289-302.  

55. Adams, J.S., Singer, F.R., Gacad, M.A. Isolation and structural identification of 1,25-dihydroxyvitamin D3 produced by cultured alveolar macrophages in sarcoidosis, (1985) Journal of Clinical Endocrinology and Metabolism, 60 (5), Pages 960-966.

56. Coldwell, R.D., Trafford, D.J.H., Makin, H.L.J. Specific estimation of 24,25-dihydroxyvitamin D in plasma by gas chromatography-mass spectrometry, (1984) Clinical Chemistry, 30 (7), Pages 1193-1198. 

57. Simpson, R.U., Wichmann, J.K., Paaren, H.E. Metabolism of 25-hydroxyvitamin D3 by rat kidney cells in culture: Isolation and identification of cis- and trans-19-nor-10-oxo-25-hydroxyvitamin D3, (1984) Archives of Biochemistry and Biophysics, 230 (1), Pages 21-29. 

58. Jones, G., Kano, K., Yamada, S. Identification of 24,25,26,27-tetranor-23-hydroxyvitamin D3 as a product of the renal metabolism of 24,25-dihydroxyvitamin D3, (1984) Biochemistry, 23 (16), Pages 3749-3754. 

59. Horst, R.L., Wovkulich, P.M., Baggiolini, E.G. (23S)-1,23,25-trihydroxyvitamin D3: Its biologic activity and role in 1a,25-dihydroxyvitamin D3 26,23-lactone biosynthesis, (1984) Biochemistry, 23 (17), Pages 3973-3979. 

60. Mayer, E., Bishop, J.E., Chandraratna, R.A.S. Isolation and identification of 1,25-dihydroxy-24-oxo-vitamin D3 and 1,23,25-trihydroxy-24-oxo-vitamin D3. New metabolites of vitamin D3 produced by a C-24 oxidation pathway of metabolism for 1,25-dihydroxyvitamin D3 present in intestine and kidney, (1983) Journal of Biological Chemistry, 258 (22), Pages 13458-13465.

61. Jones, G., Kung, M., Kano, K. The isolation and identification of two new metabolites of 25-hydroxyvitamin D3 produced in the kidney, (1983) Journal of Biological Chemistry, 258 (21), Pages 12920-12928.

62. Trafford, D.J.H., Makin, H.L.J. Studies on the presence of 25-hydroxyvitamin D in human saliva, (1983) Clinica Chimica Acta, 129 (1), Pages 19-25.

63. Ishizuka, S., Ishimoto, S., Norman, A.W. Isolation, identification, and biological activity of 23,25,26-trihydroxyvitamin D3, an in vitro and in vivo metabolite of vitamin D3, (1982) Archives of Biochemistry and Biophysics, 217 (1), Pages 264-272.

64. Tanaka, Y., Schnoes, H.K., Smith, C.M., Deluca, H.F. 1,25,26-Trihydroxyvitamin D3: Isolation identification, and biological activity, (1981) Archives of Biochemistry and Biophysics, 210 (1), Pages 104-109. 

65. Tanaka, Y., Wichmann, J.K., Schnoes, H.K., DeLuca, H.F. Isolation and identification of 23,25-dihydroxyvitamin D3, an in vivo metabolite of vitamin D3, (1981) Biochemistry, 20 (13), Pages 3875-3879. 

66. Reinhardt, T.A., Napoli, J.L., Praminik, B. 1a,25,26-trihydroxyvitamin D3: An in vivo and in vitro metabolite of vitamin D3, (1981) Biochemistry, 20 (21), Pages 6230-6235.  

67. Tanaka, Y., Wichmann, J.K., Paaren, H.E. Role of kidney tissue in the production of 25-hydroxyvitamin D3-26,23-lactone and 1a,25-dihydroxyvitamin D3-26,23-lactone, (1980) Proceedings of the National Academy of Sciences of the United States of America, 77 (11), Pages 6411-6414. 

68. Tanaka, Y., Halloran, B., Schnoes, H.K., DeLuca, H.F. In vitro production of 1,25-dihydroxyvitamin D3 by rat placental tissue, (1979) Proceedings of the National Academy of Sciences of the United States of America, 76 (10), Pages 5033-5035.  

69. Napoli, J.L., Mellon, W.S., Fivizzani, M.A. Synthesis and biological activity of 24-hydroxy-25-fluorovitamin D3. A highly potent mediator of calcium metabolism, (1979) Journal of Biological Chemistry, 254 (6), Pages 2017-2022. 

70. Okano, T., Mizuno, K., Matsuyama, N. Gas-liquid chromatography/mass spectrometric identification of previtamin D3 and vitamin D3 in the skin of vitamin D-deficient rats irradiated with ultraviolet light, (1979) Recueil des Travaux Chimiques des Pays Bas, 98 (5), Pages 253-257. 

71. Jones, G. Assay of vitamins D2 and D3, and 25-hydroxyvitamins D2 and D3 in human plasma by high-performance liquid chromatography, (1978) Clinical Chemistry, 24 (2), Pages 287-298.

72. Morisaki, M., Rubio Lightbourn, J., Ikekawa, N., Takeshita, T. Synthesis of active forms of vitamin D. V. A practical route to 1a,25 dihydroxycholesterol, (1973) Chemical and Pharmaceutical Bulletin, 21 (11), Pages 2568-2570.

73. Boomsma, F., Jacobs, H.J.C., Havinga, E., Van Der Gen, A. Studies on vitamin D and related compounds. XXIII. The structure of bischolestadienol isomers, (1973) Recueil des Travaux Chimiques des Pays Bas, 92 (12), Pages 1361-1367. 


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