Figure 12-3. Kinetic performance and normalized generated pressure drop as a function of linear velocity for 1.7 and 3.5 um particles in ultra-high performance liquid chromatography (UHPLC) and ultra-high performance supercritical fluid chromatography (UHPSFC). (A) van Deemter curves for high performance liquid chromatography with 3.5 um particles (blue dots (dark gray in print versions)), UHPLC with 1.7 um particles (red diamonds (gray in print versions)), supercritical fluid chromatography with 3.5 um particles (purple squares (black in print versions)), and UHPSFC with 1.7 um particles (green triangles (light gray in print versions)). (B) Corresponding generated column pressure drops normalized to a 1 m column.

Reproduced from Grand-Guillaume Perrenoud, A., Veuthey, J.-L., Guillaume, D., 2012. Comparison of ultra-high performance supercritical fluid chromatography and ultra-high performance liquid chromatography for analysis of pharmaceutical compounds. J. Chromatogr. A 1266, 158-167 with permission. Also see this reference for details of experimental measurements.

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