Figure 12-8. Model of total MeOH amount entering the eletrospray ionization probe using a prebackpressure regulator splitter with the sheath pump interface as a function of the ultra-high performance supercritical fluid chromatography mobile phase flow rate (x-axis) and sheath pump flow-rate (y-axis) for two different mobile phase CO₂/methanol compositions. (A) composition 95:5, (B) 80:20 and three different fixed back-pressures: 120 bar (A1, B1), 150 bar (A2, B2), and 180 bar (A3, B3). MeOH, methanol; MS, mass spectrometry; SFC, supercritical fluid chromatography.

Adapted from Grand-Guillaume Perrenoud, A., Veuthey, J.-L., Guillaume, D., 2014a. Coupling state-of-the-art supercritical fluid chromatography and mass spectrometry: from hyphenation interface optimization to high-sensitivity analysis of pharmaceutical compounds. J. Chromatogr. A 1339, 174-184 with permission.

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