Handbook of Advanced Chromatography / Mass Spectrometry Techniques
Chapter 1 - Theory and Practice of UHPLC and UHPLC-MS
by Davy Guillarme and Jean-Luc Veuthey

Figure 1-11. Separation of 103 doping agents in urine sample according to m/z and tR values. Data from electrospray ionization (ESI) positive and negative mode are plotted together. The three I.S are circled with a continuous line. A zone (dashed line) is magnified to show the selectivity of coupling ultrahigh-pressure liquid chromatography to the quadrupole time-of-flight mass spectrometer. In the magnified zone, the compounds (1) methylephedrine, (2) 3,4- methylenedioxyamphetamine, and (3) nikethamide are separated as a function of time, intensity, and m/z.

Adapted from Badoud, F., Grata, E., Perrenoud, L., Avois, L., Saugy, M., Rudaz, S., Veuthey, J.L., 2009. Fast analysis of doping agents in urine by ultra-high-pressure liquid chromatographyequadrupole time-of-flight mass spectrometry: I. Screening analysis. J. Chromatogr. A 1216, 4423-4433, with permission.

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