Handbook of Advanced Chromatography / Mass Spectrometry Techniques
Chapter 7 - Introduction to Two-Dimensional Liquid Chromatography - Theory and Practice
by Dwight R. Stoll

Figure 7-1. Simple view of the benefit of a second dimension of separation. The idea is that compounds not separated by the first dimension (1D) column are transferred as mixtures to the second dimension (2D) column for further separation.

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