Handbook of Advanced Chromatography / Mass Spectrometry Techniques
Chapter 7 - Introduction to Two-Dimensional Liquid Chromatography - Theory and Practice
by Dwight R. Stoll

Figure 7-10. Effect of sampling time (rate) on resulting LC x LC contour plot. Panel (A) sampling at the Murphy- Schure-Foley recommendation of ts = 2 1s; N = 4 samples/8 1s. As the sampling time is increased there is more remixing of 1D peaks, and resolution in the two dimensional chromatogram is lost; panel (B) sampling at N = 2; and panel (C) sampling at N = 1.

Reprinted with permission from Carr, P.W., Davis, J.M., Rutan, S.C., Stoll, D.R., 2012. Principles of online comprehensive multidimensional liquid chromatography. In: Gruska, E., Grinberg, N (Eds.), Advances in Chromatography. CRC Press, Boca Raton, FL.

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