Handbook of Advanced Chromatography / Mass Spectrometry Techniques
Chapter 7 - Introduction to Two-Dimensional Liquid Chromatography - Theory and Practice
by Dwight R. Stoll

Figure 7-22. Changes in peak width (A, B) and symmetry (C, D) for the probe compound nitropentane using two nominally identical columns prepared with sub-three micron superficially porous particles and C18 bonded phase, and the 10-port/2-position valve design shown in Fig. 7.19A. Evidence of column failure appears after just an hour of twodimensional liquid chromatography operation.

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