Figure 7-26. Instrument configuration used to study the effect of one dimensional effluent fraction composition and volume on two-dimwnsional resolution and detection sensitivity.

Reprinted with permission of Springer from Stoll, D.R., Talus, E.S., Harmes, D.C., Zhang, K., 2014. Evaluation of detection sensitivity in comprehensive two-dimensional liquid chromatography separations of an active pharmaceutical ingredient and its degradants. Anal. Bioanal. Chem. 407, 265-277. http://dx.doi.org/10.1007/s00216-014-8036-9.

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