Handbook of Advanced Chromatography / Mass Spectrometry Techniques
Chapter 7 - Introduction to Two-Dimensional Liquid Chromatography - Theory and Practice
by Dwight R. Stoll

Figure 7-28. Effect of the solvent strength of the 1D effluent in the 2D separation mode on detection sensitivity at the outlet of the 2D column. HILIC, hydrophilic interaction liquid chromatography.

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