Handbook of Advanced Chromatography / Mass Spectrometry Techniques
Chapter 7 - Introduction to Two-Dimensional Liquid Chromatography - Theory and Practice
by Dwight R. Stoll

Figure 7-29. Illustration of a system for two-dimensional liquid chromatography capable of both online dilution between dimensions and the use of packed traps instead of open sample loops in the valve interface. 1D, first dimension; 2D, second dimension.

Reprinted with permission from Gargano, A.F.G., Duffin, M., Navarro, P., Schoenmakers, P.J., 2016. Reducing dilution and analysis time in online comprehensive two-dimensional liquid chromatography by active modulation. Anal. Chem. 88, 1785-1793. http://dx.doi.org/10.1021/acs.analchem.5b04051.

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