Handbook of Advanced Chromatography / Mass Spectrometry Techniques
Chapter 7 - Introduction to Two-Dimensional Liquid Chromatography - Theory and Practice
by Dwight R. Stoll

Figure 7-7. Illustration of a box-counting method, which counts the fraction of bins in a two-dimensional separation bed that is occupied by peaks. This fraction enables correction of the total peak capacity for incomplete usage of the separation space. Circles represent coordinates of observed peaks in an experimental LC x LC separation. The red (gray line in print versions) line defines the perimeter around the bins that are considered to be occupied. LC, liquid chromatography.

Reprinted with permission from Davis, J.M., Stoll, D.R., Carr, P.W., 2008a. Dependence of effective peak capacity in comprehensive two-dimensional separations on the distribution of peak capacity between the two dimensions. Anal. Chem. 80, 8122-8134. http://dx.doi.org/10.1021/ac800933z. Copyright 2008, American Chemical Society.

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