Handbook of Advanced Chromatography / Mass Spectrometry Techniques
Chapter 7 - Introduction to Two-Dimensional Liquid Chromatography - Theory and Practice
by Dwight R. Stoll

Figure 7-8. Illustration of the use of convex hulls to estimate the fraction of separation space occupied by peaks.

Reprinted with permission from Gilar, M., Fridrich, J., Schure, M.R., Jaworski, A., 2012. Comparison of orthogonality estimation methods for the two-dimensional separations of peptides. Anal. Chem. 84, 8722-8732. http://dx.doi.org/10.1021/ac3020214. Copyright 2012, American Chemical Society.

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